Malaria is the major cause of death in Uganda with approximately 70,000 to 100,000 Ugandans dying annually from the disease.50% of the deaths are among children below five years, according to a 2013/2014 report of the Parliamentary Committee of Health.
Malaria negatively affects the economy. The budget on anti-malarial drugs is going up. There are several indirect costs due to malaria like inpatient costs of admission and blood for malaria-induced anaemia in children and pregnancy ( 50% and 30% of all blood demand is for child health and maternal health respectively). Yet, malaria is preventable and treatable, the report adds.
A recent study done in rural Uganda indicates rising cases of malaria, suggesting that more aggressive methods of controlling the disease in high-transmission areas are urgently needed, according to a new two-year surveillance study published on Monday by the American Journal of Tropical Medicine & Hygiene.
The study, led by an international team of scientists, offers the most accurate, comprehensive and up-to-date measurement of the disease burden of malaria in Uganda, which is among the highest in sub-Saharan Africa.
“Our findings suggest that current efforts at controlling malaria may not be as effective as previously believed in high-transmission areas, where the disease is the biggest threat,” said Grant Dorsey, MD, PhD, a co-author of the study and professor of infectious diseases at the University of California, San Francisco. “It’s important to tell the less happy story that we have not yet seen advances in more rural areas, including at least two sites in Uganda, where transmission has been historically high.”
In an accompanying editorial, Steven Meshnick, MD, PhD, and professor in the department of epidemiology at the University of North Carolina, Chapel Hill wrote: “The real take-home message of this study may be that malaria control in Africa requires sustained and consistent efforts over much more than two years.”
According to the study authors, the results indicate that high-transmission countries like Uganda will likely need to further scale up campaigns to distribute insecticide-treated bed nets and spray homes with insecticides, while also considering new interventions such as using malaria drugs for prevention and controlling mosquito larvae in order to match the malaria reduction successes seen elsewhere in the world.
Since 2000, global investments in many types of malaria control are estimated to have resulted in a 47 percent drop in the disease’s global mortality rate and a 58 percent decrease in the mortality rate among African children, according to the World Health Organization.
While access to the most current malaria medications has dramatically increased in Uganda, use of other recommended interventions is less widespread, the authors said. Studies show that only up to 36 percent of households have at least one long-lasting insecticide treated bed net (LLIN). Only 6 to 7 percent of households in Uganda reported receiving indoor residual spraying with insecticides between 2006 and 2011.
World Health Organization statistics indicate that an estimated 198 million people are infected each year. At least 584,000 people, mostly children in sub-Saharan Africa, were estimated to have died from malaria in 2013. Symptoms of the disease range from fever, headache, chills and vomiting to severe anemia, respiratory distress, seizures and organ failure. Malaria is curable if diagnosed and treated early with anti-malarial medications.
Comparing areas with varying levels of disease transmission
To reach an accurate assessment of the incidence of malaria in Uganda, Dorsey and his colleagues from Makerere University in Uganda; the University of California, San Francisco; Durham University in the UK; the University of Oxford and the London School of Hygiene and Tropical Medicine gathered comprehensive surveillance data over 24 months, from August 2011 to September 2013.
The study initially enrolled 755 children between the ages of 6 months and 10 years from 300 houses randomly selected from three areas of Uganda with differing malaria characteristics. While the incidence of malaria infection decreased slightly in the relatively low-transmission, peri-urban Walukuba area during the study’s 24 months, it increased in the two rural areas. Episodes of malaria per person per year rose from an average of 0.97 to 1.93 in the moderate-transmission area of Kihihi and rose from an average of 2.33 to 3.30 in Nagongera, a high-transmission rural area near the southeastern border with Kenya.
The families were provided with bed nets and had access to 24-hour medical care free of charge at a designated study clinic for episodes of fever. The children were also routinely tested for malaria every three months, whether they had symptoms or not. In addition, mosquito specimens were collected monthly from light traps strategically placed in each house to estimate the percentages of mosquitoes in the study areas that were carriers of malaria.
Healthcare workers provided over 2,500 treatments for malaria over the course of the study.
“Children in our study experienced a significantly high rate of infection, and that rate increased in the two rural areas,” said Dorsey. “Based on prior data, our higher transmission sites are very likely to be representative of most of Uganda and perhaps of most other rural areas in sub-Saharan Africa as well.”
“We have been getting used to good news in the fight against malaria, but this is not good news,” said Christopher Plowe, president of the American Society of Tropical Medicine and Hygiene. “Sixty years ago it was thought that no more research on malaria was needed—we just needed to use the tools we had. This study shows how important it is to have good data at the local level, and not rely on a one-size-fits-all approach. Research is critical to malaria elimination.”
Publish Date: Mar 18, 2015. By Deusdedit Ruhangariyo
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