• Golden Eye 0.1% w/v Eye Drops
    Golden Eye Drops Solution
  • Hypromellose 0.3% Eye Drops
    Hypromellose Eye Drops - For Dry Eyes
  • Optrex Bloodshot Eye Drops
    Optrex Bloodshot Eye Drops-ads
  • Viscotears Gel For Dry Eye
    Viscotears Gel For Dry Eye Treatment 10g
  • Golden Eye Chloramphenicol Eye
    Golden Eye Chloramphenicol Eye Ointment
  • Spatone Apple Liquid Iron
    Spatone Apple Liquid Iron Supplement-banner
  • Holland & Barrett Gentle Iron 20mg
    Holland & Barrett Gentle Iron 20mg 90 Capsules-banner
  • Vitabiotics Feroglobin Capsules
    Vitabiotics Feroglobin Capsules-banner

‘Effective’ Human Anti-HIV Vaccine Comes Closer to Reality

Business Standard
HIV injestions

An HIV vaccine research has generated key antibodies in animal models. The three study teams all demonstrated techniques for stimulating animal cells to produce antibodies that either could stop HIV from infecting human cells in the laboratory or had the potential to evolve into such antibodies.

In one study, published in Science, researchers demonstrate that a laboratory-designed molecular complex can stimulate rabbits and monkeys to produce powerful neutralizing antibodies against a tough-to-neutralize HIV strain.

The complex is similar to the part of HIV that binds to cells, a structure that has been difficult to copy as the kind of stand-alone molecule that an HIV vaccine potentially would need.

In another study, published in Cell, scientists took the first step toward confirming the prevailing hypothesis of how an HIV vaccine will need to be designed to elicit antibodies that stop a wide range of HIV strains from infecting human cells.

The researchers demonstrated in genetically modified mice that an HIV vaccine regimen likely would need to expose the immune system to one type of protein to elicit a nascent antibody with the potential to be broadly neutralizing, and then present another type of protein later on to coax a more mature form of the antibody toward final development.

In the third study, published in Science, researchers used an engineered protein to stimulate B cells in genetically modified mice to produce antibodies that are precursors of the NIAID-discovered VRC01 antibody, which can neutralize a wide range of HIV strains. This study provides strong evidence that the engineered protein can kick off the production of VRC01-class broadly neutralizing antibodies in the scientists’ mouse model by targeting VRC01-class progenitor cells and has potential to do the same in humans.

Together, the three papers represent an important starting point for developing HIV vaccines that can elicit broadly neutralizing antibodies in people.

Published: June 19, 2015. Business Standard
Copyrights © 2015 Business Standard Private Ltd

About Black Patient

Health Information & Support │www.blackpatient.com │ www.twitter.com/blackpatient │ www.facebook.com/blackpatient

Leave a Reply

Subscribe to SMS

Get text messages such as vaccination reminders, antenatal/postnatal tips, health alerts, disease prevention and more straight to your mobile phone.

Opt out from SMS / Email